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TMP269

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Cat.No：IT1810 Solarbio

CAS：1314890-29-3

Molecular Formula：C₂₅H₂₁F₃N₄O₃S

Molecular Weight：514.52

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1314890-29-3
Name	TMP269
Molecular Formula	C₂₅H₂₁F₃N₄O₃S
Molecular Weight	514.52
Solubility	Soluble in DMSO ≥5mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD26522023
SMILES	O=C(NCC1(C2=NC(C3=CC=CC=C3)=CS2)CCOCC1)C4=CC=CC(C5=NOC(C(F)(F)F)=N5)=C4
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	TMP269 is a potent and selective class IIa HDAC inhibitor.
Biological Activity	TMP269 是一种有效的，选择性的脱乙酰化酶 (HDAC) 抑制剂，能够抑制 HDAC 4/HDAC 5/HDAC 7/HDAC 9，IC50 值分别为 157 nM，97 nM，43 nM 和 23 nM。
Data Literature Source	[1]. Lobera M，et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25. [2]. Sinnett-Smith J，et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. [3]. Kikuchi S，et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Sep;29(9):1918-1927
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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