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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > TazemetostatCAS：1403254-99-8
Molecular Formula：C34H44N4O4
Molecular Weight：572.74
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1403254-99-8 |
| Name | Tazemetostat |
| Molecular Formula | C34H44N4O4 |
| Molecular Weight | 572.74 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD24849415 |
| SMILES | O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O |
| Target Point | EZH2 |
| Passage | Epigenetics |
| Background | Tazemetostat is a potent, selective EZH2 inhibitor. |
| Biological Activity | Tazemetostat (EPZ-6438) 是一种有效，选择性，口服的 EZH2 抑制剂，Ki 和 IC50 分别为2.5和11 nM。[1-3] |
| IC50 | Ki: 2.5nM(EZH2)[1] |
| Data Literature Source | [1]. Knutson SK，et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferaseEZH2. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. [2]. Knutson SK，et al. Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. Mol Cancer Ther. 2014 Apr;13(4):842-54. [3]. Majumder S，et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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