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Tacedinaline

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Cat.No：IT1780 Solarbio

CAS：112522-64-2

Molecular Formula：C₁₅H₁₅N₃O₂

Molecular Weight：269.3

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	112522-64-2
Name	Tacedinaline
Molecular Formula	C₁₅H₁₅N₃O₂
Molecular Weight	269.3
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 200-256-5
MDL	MFCD00866266
SMILES	O=C(NC1=C(N)C=CC=C1)C2=CC=C(NC(C)=O)C=C2
InChIKey	VAZAPHZUAVEOMC-UHFFFAOYSA-N
InChI	InChI=1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
PubChem CID	2746
Target Point	HDAC
Passage	DNA Damage/DNA Repair;Epigenetics;NF-κB
Background	Tacedinaline is a selective type I HDAC inhibitor.
Biological Activity	CI-994 (Tacedinaline)是组蛋白脱乙酰酶(HDAC)的抑制剂，抑制重组HDAC 1, 2 and 3的 IC50 值分别为0.9, 0.9, 1.2 μM.[1-4]
Data Literature Source	[1]. Moradei OM，et al. Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. J Med Chem. 2007 Nov 15;50(23):5543-6. [2]. Loprevite M，etal. In vitro study of CI-994，a histone deacetylase inhibitor，in non-small cell lung cancer cell lines. Oncol Res. 2005;15(1):39-48. [3]. LoRusso PM，et al. Preclinical antitumor activity of CI-994. Invest New Drugs. 1996;14(4):349-56. [4]. Graziano MJ，et al. Immunotoxicity of the anticancer drug CI-994 in rats: effects on lymphoid tissue. Arch Toxicol. 1999 Apr-May;73(3):168-74
Unit	Bottle
Specification	10mg 50mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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