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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > MivebresibCAS：1445993-26-9
Molecular Formula：C22H19F2N3O4S
Molecular Weight：459.47
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1445993-26-9 |
| Name | Mivebresib |
| Molecular Formula | C22H19F2N3O4S |
| Molecular Weight | 459.47 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30377200 |
| SMILES | CCS(=O)(NC1=CC=C(OC2=CC=C(F)C=C2F)C(C3=CN(C)C(C4=C3C=CN4)=O)=C1)=O |
| Target Point | BRD2，BRD4，BRD-T |
| Passage | Epigenetics |
| Background | It is a novel BET family bromodomain inhibitor. |
| Biological Activity | ABBV-075 是一种有效且选择性的 BET 家族溴结构域抑制剂。它以相似的亲和力结合 BRD2/4/T 的溴结构域（Ki 为 1-2.2 nM），但对 BRD3 的效力大约弱 10 倍（Ki 为 12.2 nM）。 ABBV-075 对测试的 18 种溴结构域蛋白具有高度选择性（Kd > 1 μM；对 BRD4 的选择性超过 600 倍），对 CREBBP 具有中等活性（Kd = 87 μM；对 BRD4 的选择性为 54 倍）。 [1] |
| Data Literature Source | [1] Sarthy A ， Li L ， Albert D H ，et al. Abstract 4718: ABBV-075，a novel BET family bromodomain inhibitor，represents a promising therapeutic agent for a broad spectrum of cancer indications[J]. Cancer Research，2016，76(14 Supplement):4718-4718. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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