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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > GSK3235025CAS：1616391-65-1
Molecular Formula：C20H25N5O3
Molecular Weight：383.44
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1616391-65-1 |
| Name | GSK3235025 |
| Molecular Formula | C20H25N5O3 |
| Molecular Weight | 383.44 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28411588 |
| SMILES | O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3 |
| Target Point | PRMT5 |
| Passage | Epigenetics |
| Background | GSK3235025 is a potent and selective PRMT5 inhibitor. |
| Biological Activity | EPZ015666 是有口服活性的 PRMT5抑制剂，IC50 为 22 nM。[1-2] |
| IC50 | 22nM(PRMT5)[1] |
| Data Literature Source | [1]. Chan-Penebre E，et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat Chem Biol. 2015 Jun;11(6):432-7. [2]. Kryukov GV，et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science. 2016 Mar 11;351(6278):1214-8 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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