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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > EPZ005687CAS：1396772-26-1
Molecular Formula：C32H37N5O3
Molecular Weight：539.67
Storage：Powder:-20℃，2 years
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1396772-26-1 |
| Name | EPZ005687 |
| Molecular Formula | C32H37N5O3 |
| Molecular Weight | 539.67 |
| Solubility | Soluble in DMSO ≥0.1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:-20℃，2 years |
| MDL | MFCD25372029 |
| SMILES | O=C(NCC1=C(C)C=C(C)NC1=O)C2=CC(C3=CC=C(CN4CCOCC4)C=C3)=CC5=C2C=NN5C6CCCC6 |
| Target Point | Histone Methyltransferase（EZH2） |
| Passage | Epigenetics |
| Background | EPZ005687 is a potent and selective EZH2 inhibitor. |
| Biological Activity | EPZ005687 是一种有效的，选择性的 EZH2 抑制剂，Ki 值为 24 nM，对其选择性是对 EZH1 的 50 倍，对其他 15 种甲基转移酶的 500 倍。[1-2] |
| IC50 | Ki: 24nM(EZH2)[1] |
| Data Literature Source | [1]. Knutson SK，et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012;8(11):890-6. [2]. Tang SH，et al. Effects of H3K27 methylation inhibitor EPZ005687 on apoptosis，proliferation and cell cycle of U937 cells and normal CD34 positive cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2014 Dec;22(6):1561-6 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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