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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > EPZ004777CAS：1338466-77-5
Molecular Formula：C28H41N7O4
Molecular Weight：539.67
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1338466-77-5 |
| Name | EPZ004777 |
| Molecular Formula | C28H41N7O4 |
| Molecular Weight | 539.67 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25563264 |
| SMILES | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CN(C(C)C)CCCNC(NC4=CC=C(C(C)(C)C)C=C4)=O)O3)C=C2)=NC=N1 |
| Target Point | Histone Methyltransferase（DOT1L） |
| Passage | Epigenetics |
| Background | EPZ004777 is a potent and selective DOT1L inhibitor. |
| Biological Activity | EPZ004777 是一种有效的选择性 DOT1L 抑制剂，IC50 为 0.4 nM。[1-2] |
| IC50 | 0.4nM(DOT1L)[1] |
| Data Literature Source | [1]. Daigle SR，et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer Cell. 2011 Jul 12;20(1):53-65. [2]. Chen L，et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia. 2013 Apr;27(4):813-22. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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