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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > CPI203CAS：1446144-04-2
Molecular Formula：C19H18ClN5OS
Molecular Weight：399.9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1446144-04-2 |
| Name | CPI203 |
| Molecular Formula | C19H18ClN5OS |
| Molecular Weight | 399.9 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD27997886 |
| SMILES | ClC1=CC=C(C(C2=C(N3C4=NN=C3C)SC(C)=C2C)=N[C@H]4CC(N)=O)C=C1 |
| Target Point | IL-6，BRD4，MYC |
| Passage | Epigenetics |
| Background | CPI-203 is a potent BET bromodomain inhibitor. |
| Biological Activity | CPI-203 是一种有效的，选择性的，细胞通透的 BET bromodomain 抑制剂，抑制 BRD4，IC50 值约为 37 nM。[1-2] |
| Data Literature Source | [1]. Devaiah BN，et al. BRD4 is an atypical kinase that phosphorylates serine2 of the RNA polymerase II carboxy-terminal domain. Proc Natl Acad Sci U S A. 2012 May 1;109(18):6927-32. [2]. Moros A，et al. Synergistic antitumor activity of lenalidomide with the BET bromodomain inhibitor CPI203 in bortezomib-resistant mantle cell lymphoma. Leukemia. 2014 Oct;28(10):2049-59. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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