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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > MacitentanCAS：441798-33-0
Molecular Formula：C19H20Br2N6O4S
Molecular Weight：588.27
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 441798-33-0 |
| Name | Macitentan |
| Molecular Formula | C19H20Br2N6O4S |
| Molecular Weight | 588.27 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 1308068-626-2 |
| MDL | MFCD17167076 |
| SMILES | BrC1=CN=C(OCCOC2=C(C3=CC=C(Br)C=C3)C(NS(NCCC)(=O)=O)=NC=N2)N=C1 |
| Target Point | Endothelin Receptor（ET-A，ET-B） |
| Passage | GPCR & G Protein |
| Background | Macitentan is a non-polypeptide endothelin receptor antagonist that can be used in the study of idiopathic pulmonary fibrosis and pulmonary hypertension. |
| Biological Activity | Macitentan是有口服活性，非多肽内皮素受体拮抗剂，用于治疗特发性肺纤维化和肺动脉高压。[4] |
| Data Literature Source | [1]. Corallo C，et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18(1):228. [2]. Sen S，et al. Renal，retinal and cardiac changes in type 2 diabetes are attenuated by macitentan，a dual endothelin receptor antagonist. Life Sci. 2012 Apr 13. [3]. Bruderer S，et al. Effect of cyclosporine and rifampin on the pharmacokinetics of macitentan，a tissue-targeting dual endothelin receptor antagonist. AAPS J. 2012 Mar;14(1):68-78. [4]. Kim SJ，et al. Antivascular therapy for multidrug-resistant ovarian tumors by macitentan，a dual endothelin receptor antagonist.Transl Oncol. 2012 Feb;5(1):39-47 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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