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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > ErtugliflozinCAS：1210344-57-2
Molecular Formula：C22H25ClO7
Molecular Weight：436.88
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1210344-57-2 |
| Name | Ertugliflozin |
| Molecular Formula | C22H25ClO7 |
| Molecular Weight | 436.88 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD21609259 |
| SMILES | ClC1=CC=C([C@]23O[C@@](CO)(CO3)[C@@H](O)[C@H](O)[C@H]2O)C=C1CC4=CC=C(OCC)C=C4 |
| Target Point | SGLT |
| Passage | Membrane Transporter&Ion Channel |
| Background | Ertugliflozin is a potent and selective inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2). Can be used for type 2 diabetes related research. |
| Biological Activity | Ertugliflozin (PF-04971729) 是有效的、选择性的、具有口服活性的钠离子依赖的葡萄糖协同转运蛋白2 (SGLT2) 的抑制剂。其对h-SGLT2 的 IC50 值为0.877 nM。是一种治疗2型糖尿病的临床药物[1-3]。 |
| IC50 | 0.877nM(h-SGLT2)[1-3]. |
| Data Literature Source | [1]. Mascitti V，et al. Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors. J Med Chem. 2011 Apr 28;54(8):2952-60. [2]. Miao Z，et al. Pharmacokinetics，metabolism，and excretion of the antidiabetic agent ertugliflozin (PF-04971729) in healthy male subjects. Drug Metab Dispos. 2013 Feb;41(2):445-56. [3]. Jiang M，Steyger PS. An evaluation of US patent 2015065565 (A1) for a new class of SGLT2 inhibitors for treatment 1 of type II diabetes mellitus. Expert Opin Ther Pat. 2015;25(11):1349-1352. |
| Unit | Bottle |
| Specification | 1mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
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