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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > AmbrisentanCAS：177036-94-1
Molecular Formula：C22H22N2O4
Molecular Weight：378.42
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 177036-94-1 |
| Name | Ambrisentan |
| Molecular Formula | C22H22N2O4 |
| Molecular Weight | 378.42 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 658-059-9 |
| MDL | MFCD08672619 |
| SMILES | O=C([C@H](C(OC)(C1=CC=CC=C1)C2=CC=CC=C2)OC3=NC(C)=CC(C)=N3)O |
| Target Point | Endothelin Receptor（ET-A） |
| Passage | GPCR & G Protein |
| Background | Ambrisentan is a selective ET type A receptor (ETAR) antagonist. |
| Biological Activity | Ambrisentan 是一种选择性的ET A型受体 (ETAR) 拮抗剂。[1-2] |
| Data Literature Source | [1]. Okamoto T，et al. Antifibrotic effects of Ambrisentan，an endothelin-A receptor antagonist，in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8(22):933-41. [2]. Lisk C，et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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