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SB-590885

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Cat.No：IS2180 Solarbio

CAS：405554-55-4

Molecular Formula：C₂₇H₂₇N₅O₂

Molecular Weight：453.54

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	405554-55-4
Name	SB-590885
Molecular Formula	C₂₇H₂₇N₅O₂
Molecular Weight	453.54
Solubility	Soluble in DMSO ≥1mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD16038645
SMILES	O/N=C1CCC2=CC(C3=C(NC(C4=CC=C(C=C4)OCCN(C)C)=N3)C5=CC=NC=C5)=CC=C/12
Target Point	Raf
Passage	MAPK
Background	SB-590885 is a potent B-Raf inhibitor.
Biological Activity	SB-590885 是一种有效的 B-Raf 抑制剂，Ki 值为 0.16 nM；对其选择性是对 c-Raf 的 11 倍多。[1-3]
IC50	B-Raf:0.16nM(Ki);c-Raf:1.72nM(Ki)[1-3]
Data Literature Source	[1]. King AJ，et al. Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885. Cancer Res，2006，66(23)，11100-11105. [2]. Takle AK，et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett，2006，16(2)，378-381. [3]. Smalley KS，et al. Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas. Mol Cancer Ther，2008，7(9)，2876-2883.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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