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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > PF-06651600CAS：1792180-81-4
Molecular Formula：C15H19N5O
Molecular Weight：285.34
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1792180-81-4 |
| Name | PF-06651600 |
| Molecular Formula | C15H19N5O |
| Molecular Weight | 285.34 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30343868 |
| SMILES | C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O |
| Target Point | JAK |
| Passage | JAK/STAT Signaling |
| Background | PF-06651600 is a novel, potent, selective and irreversible JAK3 inhibitor |
| Biological Activity | PF-06651600 is a potent JAK3-selective inhibitor (IC50: 33.1 nM).[1-2] |
| Data Literature Source | [1]. Telliez JB，et al. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem Biol. 2016 Dec 16;11(12):3442-3451. [2]. Thorarensen A，et al. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S，5R)-5-((7H-Pyrrolo[2，3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. J Med Chem. 2017 Mar 9;60(5):1971-1993. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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