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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Angiogenesis > PacritinibCAS：937272-79-2
Molecular Formula：C28H32N4O3
Molecular Weight：472.58
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 937272-79-2 |
| Name | Pacritinib |
| Molecular Formula | C28H32N4O3 |
| Molecular Weight | 472.58 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22572772 |
| SMILES | C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1 |
| Target Point | FLT3，JAK2 |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK;JAK/STAT Signaling |
| Background | Pacritinib, a potent JAK2 inhibitor, also inhibits FLT3. |
| Biological Activity | Pacritinib是有效的选择性Janus Kinase 2 (JAK2)和Fms-Like Tyrosine Kinase-3 (FLT3)抑制剂，无细胞试验中IC50分别为23和22 nM。[1-2] |
| Data Literature Source | [1] Hart S，et al. Leukemia，2011，25(11)，1751-1759. [2] Hart S，et al. Blood Cancer J，2011，1(11)，e44. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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