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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > NiclosamideCAS：50-65-7
Molecular Formula：C13H8Cl2N2O4
Molecular Weight：327.12
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to green yellow Solid
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| CAS | 50-65-7 |
| Name | Niclosamide |
| Molecular Formula | C13H8Cl2N2O4 |
| Molecular Weight | 327.12 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to green yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-056-8 |
| MDL | MFCD00057597 |
| SMILES | O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O |
| InChIKey | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| PubChem CID | 4477 |
| Target Point | STAT3 |
| Passage | JAK/STAT Signaling |
| Background | Salicylamide derivatives, a STAT3 inhibitor, can inhibit DNA replication. |
| Biological Activity | Niclosamide 是一种 STAT3 抑制剂，在 HeLa 细胞中，IC50 值为 0.25 μM，可以抑制 DNA 复制。[1-4] |
| Data Literature Source | [1]. Ren，X.，et al.，Identification of niclosamide as a new small-molecule inhibitor of the STAT3 signaling pathway. ACS Medicinal Chemistry Letters，2010. 1(9): p. 454-459. [2]. Wu CJ，et al. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrob Agents Chemother. 2004 Jul;48(7):2693-6. [3]. Chen，M.，et al.，The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry，2009. 48(43): p. 10267-74. [4]. Jin，Y.，et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res，2010. 70(6): p. 2516-27. |
| Unit | Bottle |
| Specification | 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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