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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > MomelotinibCAS：1056634-68-4
Molecular Formula：C23H22N6O2
Molecular Weight：414.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1056634-68-4 |
| Name | Momelotinib |
| Molecular Formula | C23H22N6O2 |
| Molecular Weight | 414.46 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD16038899 |
| SMILES | O=C(C1=CC=C(C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2)C=C1)NCC#N |
| Target Point | JAK |
| Passage | JAK/STAT Signaling |
| Background | Momelotinib is an ATP-competitive JAK1/JAK2 inhibitor. |
| Biological Activity | Momelotinib (CYT387) 是 ATP 竞争性的 JAK1/JAK2 抑制剂，IC50 值分别为 11 nM/18 nM，是对 JAK3 选择性的 10 倍左右。[1-4] |
| IC50 | JAK1:11nM;JAK2:18nM;JAK3:155nM [1-4] |
| Data Literature Source | [1]. Pardanani A，et al. CYT387，a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia，2009，23(8)，1441-1445. [2]. Monaghan KA，et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways，prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia，2011，25(12)，1891-1899. [3]. Tyner JW，et al. CYT387，a novel JAK2 inhibitor，induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood，2010，115(25)，5232-5240. [4]. Kitajima S，et al.Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS.Cancer Cell. 2018 Sep 10;34(3):439-452.e6. doi: 10.1016/j.ccell.2018.08.009 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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