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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > LY-3009120CAS：1454682-72-4
Molecular Formula：C23H29FN6O
Molecular Weight：424.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 1454682-72-4 |
| Name | LY-3009120 |
| Molecular Formula | C23H29FN6O |
| Molecular Weight | 424.51 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28411374 |
| SMILES | O=C(NC1=CC(C2=CC3=CN=C(NC)N=C3N=C2C)=C(C)C=C1F)NCCC(C)(C)C |
| Target Point | Raf |
| Passage | MAPK |
| Background | LY-3009120 is a novel and potent pan-Raf inhibitor |
| Biological Activity | LY3009120 (DP-4978) is a pan RAF inhibitor which inhibits BRAFV600E， BRAFWT and CRAFWT with IC50s of 5.8， 9.1 and 15 nM， respectively.[1-4] |
| Data Literature Source | [1]. Vakana E， et al. LY3009120， a panRAF inhibitor， has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer. Oncotarget. 2017 Feb 7;8(6):9251-9266 [2]. Chen SH， et al. Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120. Cancer Discov. 2016 Mar;6(3):300-15 [3]. Peng SB， et al. Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Cancer Cell. 2015 Sep 14;28(3):384-98 [4]. Henry JR， et al. Discovery of 1-(3，3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2，3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumo |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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