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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > LosmapimodCAS：585543-15-3
Molecular Formula：C22H26FN3O2
Molecular Weight：383.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 585543-15-3 |
| Name | Losmapimod |
| Molecular Formula | C22H26FN3O2 |
| Molecular Weight | 383.46 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07793339 |
| SMILES | CC1=C(C2=NC=C(C(NCC(C)(C)C)=O)C=C2)C=C(C(NC3CC3)=O)C=C1F |
| Target Point | p38 MAPK |
| Passage | MAPK |
| Background | Losmapimod is a potent, selective p38 MAPK inhibitor that inhibits p38α and p38β. |
| Biological Activity | Losmapimod 是一种有效，选择性，可口服的 p38 MAPK 抑制剂，抑制p38α 和 p38β 的 pKi 值分别为 8.1 和 7.6。[1-2] |
| Data Literature Source | [1]. Willette RN，et al. Differential effects of p38 mitogen-activated protein kinase and cyclooxygenase 2 inhibitors in a model of cardiovascular disease. J Pharmacol Exp Ther. 2009 Sep;330(3):964-70. [2]. Zhang XM，et al. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochem Int. 2015 Nov;90:1-8 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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