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INCB-024360

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Cat.No：II1600 Solarbio

CAS：914471-09-3

Molecular Formula：C₉H₇ClFN₅O₂

Molecular Weight：271.64

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	914471-09-3
Name	INCB-024360
Molecular Formula	C₉H₇ClFN₅O₂
Molecular Weight	271.64
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD18633286
SMILES	ON/C(C1=NON=C1N)=N/C2=CC=C(F)C(Cl)=C2
Target Point	Indoleamine 2,3-Dioxygenase (IDO)
Passage	Immunology & Inflammation;Metabolic Enzyme&Protease
Background	IDF-11774 is a HIF-1 inhibitor)
Biological Activity	IDO5L 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50 为 67 nM。[1-2]
IC50	IDO:67nM;IDO:19nM(HeLa cell)[1-2]
Data Literature Source	[1]. Yue EW，et al. Discovery of potent competitive inhibitors of indoleamine 2，3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem. 2009 Dec 10;52(23):7364-7. [2]. Huang X，et al. Synthesis of [(18) F] 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1，2，5-oxadiazole-3-carboximidamide (IDO5L): a novel potential PET probe for imaging of IDO1 expression. J Labelled Comp Radiopharm. 2015 Apr;58(4):156-62
Unit	Bottle
Specification	10mg 25mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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