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Iguratimod

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Cat.No：II1590 Solarbio

CAS：123663-49-0

Molecular Formula：C₁₇H₁₄N₂O₆S

Molecular Weight：374.37

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	123663-49-0
Name	Iguratimod
Molecular Formula	C₁₇H₁₄N₂O₆S
Molecular Weight	374.37
Solubility	Soluble in DMSO ≥1mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 808-127-0
MDL	MFCD00882374
SMILES	O=C1C2=CC(OC3=CC=CC=C3)=C(C=C2OC=C1NC([H])=O)NS(=O)(C)=O
Target Point	COX2，MIF
Passage	Immunology & Inflammation
Background	Ifosfamide is a DNA alkylator with broad-spectrum antitumor activity.
Biological Activity	Iguratimod 是一种抗风湿剂，能够有效地抑制 COX-2 的活性，IC50 值为 20 μM (7.7 μg/mL)，而对 COX-1 无作用；Iguratimod 同时为巨噬细胞移动抑制因子 (MIF) 抑制剂，IC50 值为 6.81 μM。[1-3]
IC50	COX-2:20μM;mIF:6.81μM [1-3]
Data Literature Source	[1]. Tanaka K，et al. T-614，a novel antirheumatic drug，inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts. Jpn J Pharmacol. 1995 Apr;67(4):305-14. [2]. Sun Y，et al. Anti-rheumatic drug iguratimod protects against cancer-induced bone pain and bone destruction in a rat model. Oncol Lett. 2017 Jun;13(6):4849-4856. [3]. Iguratimod，et al. Identification of Iguratimod as an Inhibitor of Macrophage Migration Inhibitory Factor (MIF) with Steroid-sparing Potential. J Biol Chem. 2016 Dec 16;291(51):26502-26514.
Unit	Bottle
Specification	5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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