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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > HO-3867CAS：1172133-28-6
Molecular Formula：C28H30F2N2O2
Molecular Weight：464.55
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1172133-28-6 |
| Name | HO-3867 |
| Molecular Formula | C28H30F2N2O2 |
| Molecular Weight | 464.55 |
| Solubility | Soluble in DMSO ≥1mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01862953 |
| SMILES | O=C1/C(CN(CC2=CC(C)(C)N(O)C2(C)C)C/C1=C\C3=CC=C(F)C=C3)=C/C4=CC=C(F)C=C4 |
| Target Point | STAT3 |
| Passage | JAK/STAT Signaling |
| Background | HO-3867 is a potent, selective STAT3 inhibitor with antitumor activity. |
| Biological Activity | HO-3867是有效,选择性的 STAT3 抑制剂，有着良好的抗肿瘤活性。[1-3] |
| Data Literature Source | [1]. Rath KS et al. HO-3867，a safe STAT3 inhibitor，is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74(8):2316-27. [2]. Tierney BJ et al. HO-3867，a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13(9):766-75 [3]. Hu Y，et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28(4):392-400 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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