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GW-5074

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Cat.No：IG2410 Solarbio

CAS：220904-83-6

Molecular Formula：C₁₅H₈Br₂INO₂

Molecular Weight：520.94

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	220904-83-6
Name	GW-5074
Molecular Formula	C₁₅H₈Br₂INO₂
Molecular Weight	520.94
Solubility	Soluble in DMSO ≥10mg/mL
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD09971042
SMILES	O=C1NC2=C(/C1=C/C3=CC(Br)=C(C(Br)=C3)O)C=C(C=C2)I
Target Point	Raf
Passage	MAPK
Background	GW 5074 is a potent and selective c-Raf inhibitor.
Biological Activity	GW 5074 是一种有效的，选择性的 c-Raf 抑制剂，IC50 值为 9 nM；对 JNK1/2/3，MEK1，MKK6/7，CDK1/2，c-Src，p38 MAP，VEGFR2 或 c-Fms 等没有作用。[1-3]
IC50	c-Raf:9nM
Data Literature Source	[1]. Chin PC，et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem，2004，90(3)，595-608. [2]. Lei Y，et al. The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res，2008，9(1)，71. [3]. Yue X，et al. Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor，GW5074. Eur J Pharmacol. 2006 Jul 1;540(1-3):57-9.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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