{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > GandotinibCAS：1229236-86-5
Molecular Formula：C23H24FN7O·HCl
Molecular Weight：469.94
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
Qty：
Size：
| CAS | 1229236-86-5 |
| Name | Gandotinib |
| Molecular Formula | C23H24FN7O·HCl |
| Molecular Weight | 469.94 |
| Solubility | Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 0.1mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD20482143 |
| SMILES | CC1=NNC(NC2=NN3C(C(CN4CCOCC4)=C2)=NC(C)=C3CC5=CC=C(C=C5F)Cl)=C1 |
| Target Point | JAK2，FLT3，FLT4，FGFR2，TYK2 和 TRKB |
| Passage | Angiogenesis; Protein Tyrosine Kinase/RTK |
| Background | Gandotinib is a potent JAK2 inhibitor that also inhibits FLT3, FLT4, FGFR2, TYK2 and TRKB. |
| Biological Activity | Gandotinib (LY2784544) 是一种有效的 JAK2 抑制剂，IC50 为 3 nM。Gandotinib (LY2784544) 也抑制FLT3，FLT4，FGFR2，TYK2 和 TRKB，IC50 分别为 4，25，32，44 和 95 nM。[1] |
| Data Literature Source | [1]. Ma L，et al. Discovery and characterization of LY2784544，a small-molecule tyrosine kinase inhibitor of JAK2V617F. Blood Cancer J. 2013，3，e109 |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
