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FR-0180204

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Cat.No：IF1180 Solarbio

CAS：865362-74-9

Molecular Formula：C₁₈H₁₃N₇

Molecular Weight：327.34

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	865362-74-9
Name	FR-0180204
Molecular Formula	C₁₈H₁₃N₇
Molecular Weight	327.34
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00056107
SMILES	NC1=NNC2=NN=C(C3=C4C=CC=CN4N=C3C5=CC=CC=C5)C=C21
Target Point	ERK
Passage	MAPK
Background	FR 180204 is a selective, ATP-competitive inhibitor of ERK.
Biological Activity	FR 180204 是一种选择性的，ERK 的 ATP 竞争性抑制剂，对 ERK1 和 ERK2 的 Ki 值分别为 0.31 μM 和 0.14 μM。[1-4]
Data Literature Source	[1]. Ohori M，et al. Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex. Biochem Biophys Res Commun. 2005 Oct 14;336(1):357-63. [2]. Ohori M，et al. FR180204，a novel and selective inhibitor of extracellular signal-regulated kinase，ameliorates collagen-induced arthritis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jan;374(4):311-6. [3]. Honda M，et al. Mesothelioma cell proliferation through autocrine activation of PDGF-ββ receptor. Cell Physiol Biochem. 2012;29(5-6):667-74. [4]. Sreekanth GP，et al. Role of ERK1/2 signaling in dengue virus-induced liver injury. Virus Res. 2014 Aug 8;188:15-26.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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