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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Flufenamic AcidCAS：530-78-9
Molecular Formula：C14H10F3NO2
Molecular Weight：281.23
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 530-78-9 |
| Name | Flufenamic Acid |
| Molecular Formula | C14H10F3NO2 |
| Molecular Weight | 281.23 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-494-1 |
| MDL | MFCD00002422 |
| SMILES | O=C(O)C1=CC=CC=C1NC2=CC=CC(C(F)(F)F)=C2 |
| InChIKey | LPEPZBJOKDYZAD-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) |
| PubChem CID | 3371 |
| Target Point | COX; AMPK; Potassium Channel; Chloride Channel; Calcium Channel; Parasite |
| Passage | PI3K/Akt/mTOR;Epigenetics;Immunology & Inflammation;Membrane Transporter&Ion Channel;Neuronal Signaling |
| Background | It is a non-steroidal anti-inflammatory agent that can inhibit the activity of COX, activate the activity of AMPK, regulate ion channels, block chloride channels and L-type Ca2+ channels, Regulates non-selective cation channels, activates potassium channels (K+ channels), etc. |
| Biological Activity | Flufenamic acid 是一种非甾体类抗炎剂，能够抑制 COX 的活性，激活 AMPK 的活性，调节离子通道，阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+ channel)，调节非选择性阳离子通道，激活钾离子通道 (K+ channel) 等。[1-3] |
| Data Literature Source | [1]. Guinamard R，et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84. [2]. Pongkorpsakol P，et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104. [3]. Pongkorpsakol P，et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100. |
| Unit | Bottle |
| Specification | 50mg 100mg 200mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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