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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > EncorafenibCAS：1269440-17-6
Molecular Formula：C22H27ClFN7O4S
Molecular Weight：540.01
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Off-white to yellow Solid
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| CAS | 1269440-17-6 |
| Name | Encorafenib |
| Molecular Formula | C22H27ClFN7O4S |
| Molecular Weight | 540.01 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25976758 |
| SMILES | O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1 |
| Target Point | Raf |
| Passage | MAPK |
| Background | Encorafenib is a highly potent RAF inhibitor. |
| Biological Activity | Encorafenib (LGX818) 是一种高效的 RAF 抑制剂，对BRAFV600E 细胞有选择性抗增殖和促凋亡活性，EC50 值为4 nM。[1-2] |
| Data Literature Source | [1]. Compounds and compositions as protein kinase inhibitors. Patent WO 2011025927 A1 [2]. Li Z，et al. Encorafenib (LGX818)，a potent BRAF inhibitor，induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370(2):332-44 |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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