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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Diclofenac AcidCAS：15307-86-5
Molecular Formula：C14H11Cl2NO2
Molecular Weight：296.15
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 15307-86-5 |
| Name | Diclofenac Acid |
| Molecular Formula | C14H11Cl2NO2 |
| Molecular Weight | 296.15 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 239-348-5 |
| MDL | MFCD00451393 |
| SMILES | O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl |
| InChIKey | DCOPUUMXTXDBNB-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19) |
| PubChem CID | 3033 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Diclofenac Acid is a potent, non-selective anti-inflammatory agent that is a COX inhibitor. The mechanism of action is to selectively cut off the action link of cyclooxygenase in the arachidonic acid metabolism series and block the synthesis pathway of prostaglandin E2 (PGE2). |
| Biological Activity | Diclofenac 是一种有效的，非选择性的抗炎剂，为 COX 的抑制剂，在 CHO 细胞中，对人 COX-1 和 COX-2 的 IC50 值分别为 4 nM，1.3 nM；Diclofenac 同时对绵羊 COX-1 和 COX-2 的 IC50 值分别为 5.1 μM，0.84 μM。[1-3] |
| Data Literature Source | [1]. Riendeau D，et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Labib MB，et al. Design，synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory，analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]. Curcelli EC，et al. Beneficial effects of diclofenac therapy on serum lipids，oxidized low-density lipoprotein and antioxidant defenses in rats. Life Sci. 2008 Apr 9;82(15-16):892-8. |
| Unit | Bottle |
| Specification | 500mg 1g |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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