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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > DabrafenibCAS：1195765-45-7
Molecular Formula：C23H20F3N5O2S2
Molecular Weight：519.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1195765-45-7 |
| Name | Dabrafenib |
| Molecular Formula | C23H20F3N5O2S2 |
| Molecular Weight | 519.56 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 689-166-9 |
| MDL | MFCD17215684 |
| SMILES | CC(C)(C)C1=NC(C2=C(F)C(NS(C3=C(F)C=CC=C3F)(=O)=O)=CC=C2)=C(C4=CC=NC(N)=N4)S1 |
| Target Point | Raf |
| Passage | MAPK |
| Background | It is an ATP-competitive Raf inhibitor. |
| Biological Activity | Dabrafenib是ATP竞争型的 Raf 抑制剂，抑制 C-Raf 和 B-RafV600E 的 IC50 分别为 5 nM 和 0.6 nM。[1-5] |
| IC50 | B-RafV600E:0.6nM;C-RAF:5nM [1-5] |
| Data Literature Source | [1]. Greger JG，et al. Combinations of BRAF，MEK，and PI3K/mTOR inhibitors overcome acquired resistance to the BRAF inhibitor GSK2118436 dabrafenib，mediated by NRAS or MEK mutations. Mol Cancer Ther，2012，11(4)，909-920. [2]. Lee S，et al. Anti-inflammatory effects of dabrafenib on polyphosphate-mediated vascular disruption. Chem Biol Interact. 2016 Jul 22. [3]. Jung B，et al. Anti-septic effects of dabrafenib on HMGB1-mediated inflammatory responses. BMB Rep. 2016 Apr;49(4):214-9. [4]. Alexander M Menzies，et al. Dabrafenib and its potential for the treatment of metastatic melanoma. Drug Des Devel Ther. 2012; 6: 391–405. [5]. Posobiec LM，et al. Early Vaginal Opening in Juvenile Female Rats Given BRAF-Inhibitor Dabrafenib Is Not Associated with Early Physiologic Sexual Maturation. Birth Defects Res B Dev Reprod Toxicol. 2015 Dec;104(6):244-52. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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