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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > CorynoxeineCAS：630-94-4
Molecular Formula：C22H26N2O4
Molecular Weight：382.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 630-94-4 |
| Name | Corynoxeine |
| Molecular Formula | C22H26N2O4 |
| Molecular Weight | 382.45 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00144292 |
| SMILES | O=C(NC1=C2C=CC=C1)[C@]32[C@@](C[C@H](/C(C(OC)=O)=C\OC)[C@@H](C=C)C4)([H])N4CC3 |
| Target Point | ERK |
| Passage | MAPK |
| Background | It is a potent ERK1/ERK 2 inhibitor during PDGF-BB-induced proliferation of vascular smooth muscle cells (VSMCs). |
| Biological Activity | Corynoxeine, 从 Uncaria rhynchophylla 的钩中分离的，是 PDGF-BB 诱导血管平滑肌细胞 (VSMCs) 增殖过程中的一种有效 ERK1/ERK 2 抑制剂。[1] |
| Data Literature Source | [1]. Kim TJ，et al. Corynoxeine isolated from the hook of Uncaria rhynchophylla inhibits rat aortic vascular smooth muscle cell proliferation through the blocking of extracellular signal regulated kinase 1/2 phosphorylation. Biol Pharm Bull. 2008 Nov;31(11):2073-8 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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