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CEP-33779

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Cat.No：IC3740 Solarbio

CAS：1257704-57-6

Molecular Formula：C₂₄H₂₆N₆O₂S

Molecular Weight：462.57

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1257704-57-6
Name	CEP-33779
Molecular Formula	C₂₄H₂₆N₆O₂S
Molecular Weight	462.57
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD22683932
SMILES	O=S(C1=CC=C(C2=CC=CN3C2=NC(NC4=CC=CC(N5CCN(C)CC5)=C4)=N3)C=C1)(C)=O
Target Point	JAK
Passage	JAK/STAT Signaling
Background	CEP-33779 is a novel, selective JAK2 inhibitor.
Biological Activity	CEP-33779是一个新颖的，选择性，有口服活性的JAK2抑制剂，IC50值为1.8±0.6 nM。[1-3]
IC50	JAK2:1.8nM;JAK3:150nM [1-3]
Data Literature Source	[1]. Dugan BJ，et al. A selective，orally bioavailable 1，2，4-triazolo[1，5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779. J Med Chem. 2012 Jun 14;55(11):5243-54. [2]. Seavey MM，et al. Therapeutic efficacy of CEP-33779，a novel selective JAK2 inhibitor，in a mouse model of colitis-induced colorectal cancer. Mol Cancer Ther. 2012 Apr;11(4):984-93. [3]. Tang SJ，et al. CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function. Biochem Pharmacol. 2014 Sep 15;91(2):144-56
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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