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Binimetinib

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Cat.No：IB2430 Solarbio

CAS：606143-89-9

Molecular Formula：C₁₇H₁₅BrF₂N₄O₃

Molecular Weight：441.23

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	606143-89-9
Name	Binimetinib
Molecular Formula	C₁₇H₁₅BrF₂N₄O₃
Molecular Weight	441.23
Solubility	Soluble in DMSO ≥5mg/mL
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD22124525
SMILES	BrC1=CC=C(C(F)=C1)NC2=C(C3=C(C=C2C(NOCCO)=O)N(C=N3)C)F
Target Point	MEK
Passage	MAPK
Background	Binimetinib is a selective MEK1/2 inhibitor.
Biological Activity	Binimetinib (MEK162) 是口服和选择性的 MEK1/2 抑制剂，IC50 为12 nM。[1-5]
Data Literature Source	[1]. J Pheneger，et al. 2006，ACR Annual Scientific Meeting. Abst 794. [2]. Serra V，et al. RSK3/4 mediate resistance to PI3K pathway inhibitors in breast cancer. J Clin Invest，2013，123(6)，2551-2563. [3]. Kiessling MK，et al. Mutant HRAS as novel target for MEK and mTOR inhibitors. Oncotarget. 2015 Dec 8;6(39):42183-96. [4]. Cheng H，et al. PIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling. Oncogene. 2016 Jun 9;35(23):2961-70. [5]. Seip K，et al. Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. Oncotarget. 2016 Apr 12;7(15):19997-20015
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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