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AZD-1208

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Cat.No：IA4500 Solarbio

CAS：1204144-28-4

Molecular Formula：C₂₁H₂₁N₃O₂S

Molecular Weight：379.48

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	1204144-28-4
Name	AZD-1208
Molecular Formula	C₂₁H₂₁N₃O₂S
Molecular Weight	379.48
Solubility	Soluble in DMSO ≥5mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD25976757
SMILES	O=C(NC/1=O)SC1=C/C2=C(N3C[C@H](N)CCC3)C(C4=CC=CC=C4)=CC=C2
Target Point	Pim
Passage	JAK/STAT Signaling
Background	AZD1208 is a novel, highly selective PIM inhibitor.
Biological Activity	AZD1208 是一种新颖，可口服，具有高度选择性的 PIM 抑制剂。[1-3]
Data Literature Source	[1]. Dakin LA，et al. Discovery of novel benzylidene-1，3-thiazolidine-2，4-diones as potent and selective inhibitors of the PIM-1，PIM-2，and PIM-3 protein kinases. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. [2]. Kreuz S，et al. Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas. Mol Cancer. 2015 Dec 8;14:205. [3]. Harada M，et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget. 2015 Nov 10;6(35):37930-47
Unit	Bottle
Specification	2mg 5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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