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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Autophagy > AS-1842856CAS：836620-48-5
Molecular Formula：C18H22FN3O3
Molecular Weight：347.38
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 836620-48-5 |
| Name | AS-1842856 |
| Molecular Formula | C18H22FN3O3 |
| Molecular Weight | 347.38 |
| Solubility | Soluble in DMSO ≥1mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30718173 |
| SMILES | O=C(C1=CN(CC)C2=C(C(N)=C(F)C(NC3CCCCC3)=C2)C1=O)O |
| Target Point | Autophagy;Foxo1 |
| Passage | Autophagy |
| Background | AS-1842856 is a specific Foxo1 inhibitor, which effectively inhibits autophagy. |
| Biological Activity | AS1842856 是具有细胞可透性的抑制剂，抑制Foxo1的转录活性，IC50=33 nM。AS1842856 可直接结合活化的Foxo1，但不结合Ser256位磷酸化的Foxo1。AS1842856 可抑制自噬。[1] |
| IC50 | Foxo1(In HepG2 cells): 33nM [1] |
| Data Literature Source | [1] Takeyuki Nagashima，et al.Mol Pharmacol.2010，78(5):961-970. |
| Unit | Bottle |
| Specification | 2mg 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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