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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > JAK/STAT > AS-1517499CAS：919486-40-1
Molecular Formula：C20H20ClN5O2
Molecular Weight：397.86
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 919486-40-1 |
| Name | AS-1517499 |
| Molecular Formula | C20H20ClN5O2 |
| Molecular Weight | 397.86 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD24038757 |
| SMILES | O=C(C1=CN=C(NCCC2=CC=C(O)C(Cl)=C2)N=C1NCC3=CC=CC=C3)N |
| Target Point | STAT6 |
| Passage | JAK/STAT Signaling |
| Background | AS-1517499 is a potent STAT6 inhibitor. STAT6 protein is activated by IL-4 and IL-13 and plays an important role in Th2 differentiation. Therefore, STAT6 may be an excellent therapeutic target for various allergic diseases, including asthma and atopic diseases. |
| Biological Activity | AS1517499是一种新型有效的STAT6抑制剂，IC50为21 nM。[1] |
| Data Literature Source | [1] Nagashima S，et al. Bioorg Med Chem. 2007，15(2):1044-55. [2] Chiba Y，et al. Am J Respir Cell Mol Biol. 2009，41(5):516-24. [3] Nappo G，et al. Oncogenesis. 2017，6(5):e342. [4] Kim MJ，et al. Cell Physiol Biochem. 2018，45(5):1863-1877. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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