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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > APS-2-79CAS：2002381-31-7
Molecular Formula：C23H21N3O3·HCl
Molecular Weight：423.89
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2002381-31-7 |
| Name | APS-2-79 |
| Molecular Formula | C23H21N3O3·HCl |
| Molecular Weight | 423.89 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD30536203 |
| SMILES | CC1=CC(OC2=CC=CC=C2)=CC=C1NC3=C4C=C(OC)C(OC)=CC4=NC=N3.Cl |
| Target Point | MEK |
| Passage | MAPK |
| Background | APS-2-79 is a novel and potent MAPK antagonist that modulates KSR-dependent MAPK signaling by antagonizing the RAF heterodimer and the conformational changes required to phosphorylate and activate KSR-bound MEK. |
| Biological Activity | APS-2-79是一种MAPK拮抗剂，可以通过拮抗RAF的异源二聚及KSR结合的MEK磷酸化、激活所需的构象变化，来调节KSR依赖的MAPK信号通路。IC50=120 ± 23 nM。[1] |
| Data Literature Source | [1] Neil S. Dhawan，et al. Nature. 2016，537: 112-116. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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