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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Agmatine SulfateCAS：2482-00-0
Molecular Formula：C5H14N4·H2SO4
Molecular Weight：228.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2482-00-0 |
| Name | Agmatine Sulfate |
| Molecular Formula | C5H14N4·H2SO4 |
| Molecular Weight | 228.27 |
| Solubility | Soluble in Water ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 219-617-3 |
| MDL | MFCD00013109 |
| SMILES | NC(NCCCCN)=N.O=S(O)(O)=O |
| Target Point | Imidazoline Receptor，NO Synthase |
| Passage | GPCR & G Protein;Neuronal Signaling |
| Background | Agmatine Sulfate plays a regulatory role on multiple targets, such as neurotransmitter system, ion channel, nitric oxide synthesis. It is an endogenous agonist and NO synthase inhibitor of imidazoline receptor. |
| Biological Activity | Agmatine sulfate在多个靶点上发挥调节作用，如神经递质系统，离子通道，一氧化氮合成。它是 imidazoline receptor 的内源性激动剂和 NO synthase 抑制剂。[1-7] |
| Data Literature Source | [1]. Li G，et al. Agmatine: an endogenous clonidine-displacing substance in the brain. Science. 1994 Feb 18;263(5149):966-9. [2]. Reis DJ，et al. Is agmatine a novel neurotransmitter in brain Trends Pharmacol Sci. 2000 May;21(5):187-93. [3]. Galea E，et al. Inhibition of mammalian nitric oxide synthases by agmatine，an endogenouspolyamine formed by decarboxylation of arginine. Biochem J. 1996 May 15;316 ( Pt 1):247-9. [4]. Morrissey JJ，et al. Agmatine activation of nitric oxide synthase in endothelial cells. Proc Assoc Am Physicians. 1997 Jan;109(1):51-7. [5]. Zomkowski AD，et al. Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport. 2002 Mar 25;13(4):387-91. [6]. Ahn SS，et al. Effects of agmatine on blood-brain barrier stabilization assessed by permeability MRI in a rat model of transient cerebral ischemia. AJNR Am J Neuroradiol. 2015 Feb;36(2):283-8. [7]. Neis VB，et al. Agmatine enhances antidepressant potency of MK-801 and conventional antidepressants in mice. Pharmacol Biochem Behav. 2015 Mar;130:9-14 |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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