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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > XanthohumolCAS：6754-58-1
Molecular Formula：C21H22O5
Molecular Weight：354.4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Off-white to yellow Solid
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| CAS | 6754-58-1 |
| Name | Xanthohumol |
| Molecular Formula | C21H22O5 |
| Molecular Weight | 354.4 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Off-white to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00210576 |
| SMILES | CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=CC=C(C=C2)O)O)C |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | Xanthohumol is an inhibitor of DGAT， COX-1 and COX-2 with antitumor and antiangiogenic activities. Xanthohumol also has activity against a variety of viruses. |
| Biological Activity | Xanthohumol 是从啤酒花中分离到的黄酮类化合物，是 DGAT，COX-1 和 COX-2 的抑制剂，具有抗肿瘤，抗血管生成的作用。[1-4] |
| Data Literature Source | [1]. Luzak B，et al. Xanthohumol from hop cones (Humulus lupulus L.) prevents ADP-induced platelet reactivity. Arch Physiol Biochem. 2016 Nov 18:1-7. [2]. Arnaiz-Cot JJ，et al. Xanthohumol modulates calcium signaling in rat ventricular myocytes: Possible Antiarrhythmic properties. J Pharmacol Exp Ther. 2016 Nov 4. pii: jpet.116.236588. [3]. Gallo C，et al. Hop derived flavonoid xanthohumol inhibits endothelial cell functions via AMPK activation. Oncotarget. 2016 Aug 1. [4]. Chen PH，et al. The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death. Neuropharmacology. 2016 Nov;110(Pt A):362-75 |
| Unit | Bottle |
| Specification | 5mg 10mg 20mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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