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ZM-336372

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Cat.No：IZ0250 Solarbio

CAS：208260-29-1

Molecular Formula：C₂₃H₂₃N₃O₃

Molecular Weight：389.45

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to yellow Solid

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Product Information

CAS	208260-29-1
Name	ZM-336372
Molecular Formula	C₂₃H₂₃N₃O₃
Molecular Weight	389.45
Solubility	Soluble in DMSO ≥5mg/mL;Soluble in Water ＜ 1mg/mL
Purity	≥98%
Appearance	White to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD02683971
SMILES	O=C(NC1=CC=C(C)C(NC(C2=CC=C(O)C=C2)=O)=C1)C3=CC=CC(N(C)C)=C3
InChIKey	PYEFPDQFAZNXLI-UHFFFAOYSA-N
InChI	InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
PubChem CID	5730
Target Point	C-Raf
Passage	MAPK
Background	ZM 336372 is a potent inhibitor of protein kinase c-Raf.
Biological Activity	ZM 336372 是一种有效的蛋白激酶 c-Raf 抑制剂。在含有 0.1 mM ATP 的情况下，IC 50 值为 0.07 μM。[1-2]
Data Literature Source	[1]. Hall-Jackson CA，et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol. 1999 Aug;6(8):559-68. [2]. Van Gompel JJ，et al. ZM336372，a Raf-1 activator，suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Mol Cancer Ther. 2005 Jun;4(6):910-7.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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