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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > XMD-8-92CAS：1234480-50-2
Molecular Formula：C26H30N6O3
Molecular Weight：474.55
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light green to green Solid
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| CAS | 1234480-50-2 |
| Name | XMD-8-92 |
| Molecular Formula | C26H30N6O3 |
| Molecular Weight | 474.55 |
| Solubility | Soluble in DMSO ≥5mg/mL(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Light green to green Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD18782742 |
| SMILES | CN(C1=O)C2=CN=C(N=C2N(C3=C1C=CC=C3)C)NC4=C(C=C(C=C4)N5CCC(CC5)O)OCC |
| Target Point | BMK1，ERK |
| Passage | MAPK |
| Background | XMD8-92 is a selective ERK5/BMK1 inhibitor. |
| Biological Activity | XMD8-92 是一种选择性的 ERK5/BMK1 抑制剂，Kd 为 80 nM。[1-3] |
| Data Literature Source | [1]. Yang Q，et al. Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein.Cancer Cell. 2010 Sep 14;18(3):258-67. [2]. Yang Q，et al. Targeting the BMK1 MAP kinase pathway in cancer therapy. Clin Cancer Res. 2011 Jun 1;17(11):3527-32. [3]. Umapathy G，et al. The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma. Sci Signal. 2014 Oct 28;7(349):ra102 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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