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Vesatolimod

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Cat.No：IV0740 Solarbio

CAS：1228585-88-3

Molecular Formula：C₂₂H₃₀N₆O₂

Molecular Weight：410.51

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to light yellow Solid

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Product Information

CAS	1228585-88-3
Name	Vesatolimod
Molecular Formula	C₂₂H₃₀N₆O₂
Molecular Weight	410.51
Solubility	Soluble in DMSO ≥1mg/mL(Need ultrasonic)
Purity	≥98%
Appearance	White to light yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD25372045
SMILES	O=C1NC2=C(N)N=C(OCCCC)N=C2N(CC3=CC=CC(CN4CCCC4)=C3)C1
Target Point	Toll-like Receptor (TLR)
Passage	Immunology & Inflammation
Background	Vesatolimod is a novel potent and selective small molecule agonist of Toll-like receptor 7 (TLR-7)
Biological Activity	Vesatolimod (GS-9620) is a potent， selective and orally active agonist of Toll-Like Receptor (TLR7) with an EC50 of 291 nM.[1-3]
IC50	EC50: 291 nM (TLR7)， 9 μM (TLR8)[3]
Data Literature Source	[1]. Rebbapragada I， et al. Molecular Determinants of GS-9620-Dependent TLR7 Activation. PLoS One. 2016 Jan 19;11(1):e0146835. [2]. Lanford RE， et al. GS-9620， an Oral Agonist of Toll-Like Receptor-7， Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees. Gastroenterology. 2013 Feb 13. pii: S0016-5085(13)00169-8. [3]. D Tumas， et al. Preclinical Characterization of GS-9620， A Potent and Selective Oral TLR7 Agonist.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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