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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > TrametinibCAS：871700-17-3
Molecular Formula：C26H23FIN5O4
Molecular Weight：615.39
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 871700-17-3 |
| Name | Trametinib |
| Molecular Formula | C26H23FIN5O4 |
| Molecular Weight | 615.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD17215075 |
| SMILES | CC(NC1=CC=CC(N(C2=O)C(C(C(N2C3CC3)=O)=C(N4C)NC5=CC=C(C=C5F)I)=C(C4=O)C)=C1)=O |
| Target Point | MEK |
| Passage | MAPK |
| Background | Trametinib is a potent MEK inhibitor. |
| Biological Activity | Trametinib DMSO solvate 是有效的 MEK 抑制剂，抑制MEK1 和 MEK2的IC50 约为 2 nM。[1-5] |
| Data Literature Source | [1]. Yamaguchi T，et al. Suppressive effect of an orally active MEK1/2 inhibitor in two different animal models for rheumatoid arthritis: a comparison with leflunomide. Inflamm Res，2012，61(5)，445-454. [2]. Yamaguchi T，et al. Antitumor activities of JTP-74057 (GSK1120212)，a novel MEK1/2 inhibitor，on colorectal cancer cell lines in vitro and in vivo. Int J Oncol，2011，39(1)，23-31. [3]. Abe H，et al. Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate). ACS Med Chem Lett. 2011 Feb 28;2(4):320-4. [4]. Liu H，et al. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discov. 2018 Mar;8(3):354-369. [5]. Lai J，et al. Elimination of melanoma by sortase A-generated TCR-like antibody-drug conjugates (TL-ADCs) targeting intracellular melanoma antigen MART-1. Biomaterials. 2018 Sep;178:158-169 |
| Unit | Bottle |
| Specification | 10mg 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
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