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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > MAPK > TAK-632CAS：1228591-30-7
Molecular Formula：C27H18F4N4O3S
Molecular Weight：554.52
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1228591-30-7 |
| Name | TAK-632 |
| Molecular Formula | C27H18F4N4O3S |
| Molecular Weight | 554.52 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-256-5 |
| MDL | MFCD26960965 |
| SMILES | O=C(NC1=CC(OC2=CC=C3N=C(NC(C4CC4)=O)SC3=C2C#N)=CC=C1F)CC5=CC=CC(C(F)(F)F)=C5 |
| Target Point | AuroraB，C-Raf，B-Raf，FGFR3，PDGFRβ |
| Passage | MAPK |
| Background | TAK-632 is a potent pan-RAF inhibitor. |
| Biological Activity | TAK-632 是一种有效的 pan-RAF 抑制剂，作用于 CRAF，BRAFV600E 和 BRAFWT，IC50 分别为 1.4，2.4 和 8.3 nM。[1-2] |
| Data Literature Source | [1]. Okaniwa M，et al. Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design，synthesis，and biological evaluation of C-7-substituted 1，3-benzothiazole derivatives. J Med Chem. 2013 Aug 22;56(16):6478-94. [2]. Nakamura A，et al. Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma. Cancer Res. 2013 Oct 11. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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