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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Epigenetics > BirabresibCAS：202590-98-5
Molecular Formula：C25H22ClN5O2S
Molecular Weight：491.99
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 202590-98-5 |
| Name | Birabresib |
| Molecular Formula | C25H22ClN5O2S |
| Molecular Weight | 491.99 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26960949 |
| SMILES | O=C(NC1=CC=C(O)C=C1)C[C@H]2C3=NN=C(C)N3C4=C(C(C)=C(C)S4)C(C5=CC=C(Cl)C=C5)=N2 |
| Target Point | Epigenetic Reader Domain |
| Passage | Epigenetics |
| Background | Birabresib is a potent BET bromodomain inhibitor. |
| Biological Activity | Birabresib是一种有效的 BRD2/3/4 抑制剂，IC50 值为 92-112 nM[1]。 |
| IC50 | 92-112nM(BRD2，BRD3，BRD4)[1] |
| Data Literature Source | [1]. J. Kay Noel，et al. Abstract C244: Development of the BET bromodomain inhibitor OTX015. Mol Cancer Ther November 2013 12; C244. [2]. Marie-Magdelaine Coudé，et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10; 6(19): 17698–17712. [3]. Lu P，et al. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12;6:24100 [4]. Vázquez R，et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with everolimus. Oncotarget. 2017 Jan 31;8(5):7598-7613 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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