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Sirtinol

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Cat.No：IS1890 Solarbio

CAS：410536-97-9

Molecular Formula：C₂₆H₂₂N₂O₂

Molecular Weight：394.47

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	410536-97-9
Name	Sirtinol
Molecular Formula	C₂₆H₂₂N₂O₂
Molecular Weight	394.47
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD00810186
SMILES	O=C(NC(C1=CC=CC=C1)C)C2=CC=CC=C2/N=C/C3=C4C=CC=CC4=CC=C3O
Target Point	SIRT1，2
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	Sirtinol is a specific SIRT1 and SIRT2 inhibitor
Biological Activity	Sirtinol 是 sirtuin 的抑制剂，对 ySir2，hSIRT2 和 hSIRT2 的 IC50 值分别为 48 μM，57.7 μM 和 131 μM。[1-4]
IC50	ySir2:48μM;hSIRT2:57.7μM;hSIRT1:131μM [1-4]
Data Literature Source	[1]. Wang J，et al. Sirtinol，a class III HDAC inhibitor，induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells. Int J Oncol. 2012 Sep;41(3):1101-1109. [2]. Fong Y，et al. The antiproliferative and apoptotic effects of sirtinol，a sirtuin inhibitor on human lung cancer cells by modulating Akt/β-catenin-Foxo3a axis. ScientificWorldJournal. 2014;2014:937051. [3]. Tsai YF，et al. Sirtinol inhibits neutrophil elastase activity and attenuates lipopolysaccharide-mediated acute lung injury in mice. Sci Rep. 2015 Feb 10;5:8347. [4]. Mai A，et al. Design，synthesis，and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem. 2005 Dec 1;48(24):7789-95.
Unit	Bottle
Specification	5mg 10mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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