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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > DNA Damage & DNA Repai > DomatinostatCAS：910462-43-0
Molecular Formula：C23H21N5O3S
Molecular Weight：447.51
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to brown Solid
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| CAS | 910462-43-0 |
| Name | Domatinostat |
| Molecular Formula | C23H21N5O3S |
| Molecular Weight | 447.51 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Light yellow to brown Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28155264 |
| SMILES | O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2 |
| Target Point | HDAC1，2，3，11 |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB |
| Background | Domatinostat is a selective class I HDAC inhibitor. |
| Biological Activity | Domatinostat 是一种 I 型 HDAC 抑制剂，能够抑制 HDAC1，HDAC2，和 HDAC3 的活性，IC50 值分别为 1.20 μM，1.12 μM 和 0.57 μM；同时能够抑制组蛋白赖氨酸特异性脱甲基酶1 (Lysine specific demethylase 1) 的活性[1-4]。 |
| Data Literature Source | [1]. Pinkerneil M，et al. Evaluation of the Therapeutic Potential of the Novel Isotype Specific HDAC Inhibitor 4SC-202 in Urothelial Carcinoma Cell Lines. Target Oncol. 2016 Dec;11(6):783-798. [2]. Zhijun H，et al. Pre-clinical characterization of 4SC-202，a novel class I HDAC inhibitor，against colorectal cancer cells. Tumour Biol. 2016 Aug;37(8):10257-67. [3]. Fu M，et al. 4SC-202 activates ASK1-dependent mitochondrial apoptosis pathway to inhibit hepatocellular carcinoma cells. Biochem Biophys Res Commun. 2016 Mar 4;471(2):267-73 [4]. S.W.Henning，et al. Preclinical characterization of 4SC-202，a noval isotype specific HDAC inhibitor. |
| Unit | Bottle |
| Specification | 2mg 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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