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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Endocrinology & Hormones > ApalutamideCAS：956104-40-8
Molecular Formula：C21H15F4N5O2S
Molecular Weight：477.44
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 956104-40-8 |
| Name | Apalutamide |
| Molecular Formula | C21H15F4N5O2S |
| Molecular Weight | 477.44 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 807-449-9 |
| MDL | MFCD22380626 |
| SMILES | O=C(NC)C1=CC=C(N(C(N(C2=CC(C(F)(F)F)=C(C#N)N=C2)C3=O)=S)C43CCC4)C=C1F |
| Target Point | Androgen Receptor |
| Passage | Endocrinology & Hormones |
| Background | Apalutamide is a selective, competitive androgen receptor inhibitor. |
| Biological Activity | Apalutamide (ARN-509) 是有效, 竞争性的 雄激素受体 (AR) 拮抗剂, IC50 为 16 nM[1]。 |
| IC50 | IC50: 16nM (Androgen receptor) [1] |
| Data Literature Source | [1]. Clegg NJ， et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15; 72 (6) :1494-503. [2]. Smith MR， et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509) ， a Potent Androgen Receptor Antagonist， in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838 (16) 30133 |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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