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Sofosbuvir

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Cat.No：IS1830 Solarbio

CAS：1190307-88-0

Molecular Formula：C₂₂H₂₉FN₃O₉P

Molecular Weight：529.45

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：White to off-white Solid

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Product Information

CAS	1190307-88-0
Name	Sofosbuvir
Molecular Formula	C₂₂H₂₉FN₃O₉P
Molecular Weight	529.45
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	White to off-white Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 695-717-4
MDL	MFCD26523124
SMILES	O=C1N([C@H]2[C@]([C@H](O)[C@@H](CO[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O)O2)(C)F)C=CC(N1)=O
Target Point	HCV
Passage	Anti-infection
Background	Sofosbuvir is an NS5B polymerase inhibitor of HCV
Biological Activity	Sofosbuvir (PSI-7977) 是 HCV RNA复制抑制剂，EC50 为92 nM。[1-4]
Data Literature Source	[1]. Murakami E，et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285(45):34337-47. [2]. Lam AM，et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68. [3]. Sofia MJ，et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53(19):7202-18. [4]. Zhang X，et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.
Unit	Bottle
Specification	5mg 10mg 20mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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