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Lomustine

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Cat.No：IL1530 Solarbio

CAS：13010-47-4

Molecular Formula：C₉H₁₆ClN₃O₂

Molecular Weight：233.7

Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	13010-47-4
Name	Lomustine
Molecular Formula	C₉H₁₆ClN₃O₂
Molecular Weight	233.7
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
EC	EINECS 235-859-2
MDL	MFCD00012392
SMILES	O=C(NC1CCCCC1)N(CCCl)N=O
InChIKey	GQYIWUVLTXOXAJ-UHFFFAOYSA-N
InChI	InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
PubChem CID	3950
Target Point	DNA Alkylator
Passage	DNA Damage/DNA Repair
Background	It is a DNA alkylator with antitumor activity. Suppresses cancer cells by damaging DNA and preventing cell division.
Biological Activity	Lomustine 是一种 DNA 烷化剂 (DNA alkylator)，具有抗肿瘤活性。[1-3]
Data Literature Source	[1]. Wang P，et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361. [2]. Harvey KA，et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56. [3]. Yagiz K，et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401
Unit	Bottle
Specification	100mg 200mg 500mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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