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G007-LK

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Cat.No：IG2130 Solarbio

CAS：1380672-07-0

Molecular Formula：C₂₅H₁₆ClN₇O₃S

Molecular Weight：529.96

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Off-white to yellow Solid

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Product Information

CAS	1380672-07-0
Name	G007-LK
Molecular Formula	C₂₅H₁₆ClN₇O₃S
Molecular Weight	529.96
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Off-white to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
MDL	MFCD28167833
SMILES	ClC1=C(C=CC=C1)N2C(/C=C/C3=NN=C(C4=CC=C(C#N)C=C4)O3)=NN=C2C5=CC=C(S(C)(=O)=O)C=N5.[(E)]
Target Point	PARP
Passage	Cell Cycle;DNA Damage/DNA Repair; Epigenetics
Background	G007-LK is a potent and selective tankyrase inhibitor.
Biological Activity	G007-LK is a potent and selective inhibitor of TNKS1 and TNKS2， with IC50s of 46 nM and 25 nM， respectively.[1-3]
Data Literature Source	[1]. Voronkov A， et al. Structural basis and SAR for G007-LK， a lead stage 1，2，4-triazole based specific tankyrase 1/2 inhibitor. J Med Chem. 2013 Apr 11;56(7):3012-23. [2]. Norum JH， et al. The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology. Biol Res. 2018 Jan 9;51(1):3. [3]. Xin Chen， et al. Tankyrase inhibitors suppress hepatocellular carcinoma cell growth via modulating the Hippo cascade. PLoS One. 2017 Sep 6;12(9):e0184068.
Unit	Bottle
Specification	2mg 5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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