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My Cart> Small Molecule Compounds > Anti-Infection > Antibiotic > Daunorubicin HydrochlorideCAS：23541-50-6
Molecular Formula：C27H29NO10·HCl
Molecular Weight：563.98
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：Red Solid
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| CAS | 23541-50-6 |
| Name | Daunorubicin Hydrochloride |
| Molecular Formula | C27H29NO10·HCl |
| Molecular Weight | 563.98 |
| Solubility | Soluble in Water/DMSO ≥10mg/mL |
| Purity | HPLC≥98% |
| Appearance | Red Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-723-4 |
| MDL | MFCD04974507 |
| SMILES | O=C(C(C(OC)=CC=C1)=C1C2=O)C3=C2C(O)=C(C[C@@](O)(C(C)=O)C[C@@H]4O[C@@]5([H])C[C@H](N)[C@H](O)[C@H](C)O5)C4=C3O.[H]Cl |
| InChIKey | GUGHGUXZJWAIAS-QQYBVWGSSA-N |
| InChI | InChI=1S/C27H29NO10.ClH/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33;/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3;1H/t10-,14-,16-,17-,22+,27-;/m0./s1 |
| PubChem CID | 62770 |
| Target Point | Antibiotic;Topoisomerase |
| Passage | Anti-infection;DNA Damage/DNA Repair |
| Background | Daunorubicin Hydrochloride is an anthracycline antibiotic and a topoisomerase II (Topo II) inhibitor that inhibits DNA and RNA synthesis. Daunorubicin Hydrochloride has potent antitumor activity， inhibiting cancer cell viability and inducing apoptosis and necrosis. |
| Biological Activity | Daunorubicin hydrochloride是具有有效抗肿瘤活性的DNA拓扑异构酶II抑制剂[1-4]。 |
| Data Literature Source | [1]. Lehmann M，et al. Activity of topoisomerase inhibitors daunorubicin，idarubicin，and aclarubicin in the Drosophila Somatic Mutation and Recombination Test. Environ Mol Mutagen. 2004;43(4):250-7. [2]. Svensson SP，et al. Melanin inhibits cytotoxic effects of Doxorubicin and Daunorubicin in MOLT 4 cells. Pigment Cell Res. 2003 Aug;16(4):351-4 [3]. Gervasoni JE Jr，et al. An effective in vitro antitumor response against human pancreatic carcinoma with paclitaxel and Daunorubicin by induction of both necrosis and apoptosis. Anticancer Res. 2004 Sep-Oct;24(5A):2617-26 [4]. Arozal W，et al. Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions. Toxicology. 2011 Jan 11;279(1-3):91-9 |
| Unit | Bottle |
| Specification | 5mg 10mM*1mL in DMSO 10mM*1mL in Water 10mg 20mg 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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